skull base radionecrosis in nasopharyngeal carcinoma
Conditions
Interventions
Experimental group:coated stent implantation + operative treatment
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients with severe headache, nasal odor and repeated nasal bleeding after radiotherapy for nasopharyngeal carcinoma; 2.sbORN confirmed by endoscopy and imaging, and abscess cavity formation after necrosis; 3.ICA level of involvement 1-4.
Exclusion criteria
Exclusion criteria: 1.Patients diagnosed by pathology as residual nasopharyngeal carcinoma or recurrence of nasopharyngeal carcinoma after radiotherapy; 2.Lack of cooperation or understanding, and inability to complete the survey; 3.Patients who refuse to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EORTC Quality of Life measurement QLQ-C30 (V3.0); | — |
Secondary
| Measure | Time frame |
|---|---|
| Headache VAS score;EORTC Quality of Life Scale (Head and neck scale) QLQ-H&N35;CRP, hypersensitive CRP, inflammatory factors, tumor necrosis factor, etc;Nasal sinus Outcome Test -22 (SNOT-22);SDS/SAS self-rating scale;Cranial nerve function assessment of twelve pairs;Valve survival: MRI blood supply, endoscopy (score, color scale, etc.);One-year and two-year survival rates; | — |
Countries
China
Contacts
Public ContactZhang Weitian
Shanghai Sixth People's Hospital
Outcome results
None listed