Premature ovarian failure
Conditions
Interventions
A group:Conventional estrogen progesterone replacement therapy (Traditional therapy)t
B group:Routine estrogen progesterone replacement therapy combined with oral niacin
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Aged 20-40 years; 2.Sporadic menstruation or menopause for at least 4 months, serum basal FSH>25U/L at least 2 times (interval >4 weeks); 3.Have low estrogen symptoms like hot flashes,sweating,and mood swing, etc.; 4.Have good function of heart,liver,kidney and coagulation,no history of internal and surgical diseases and malignant tumor; 5.Normal chromosome and no history of severe familial genetic disease.
Exclusion criteria
Exclusion criteria: 1.Secondary ovarian insufficiency(e.g.hypothalamic cause); 2.Abnormal karyotyping (e.g. turner syndrome, fragile X syndrome); 3.History of previous malignant or ovarian tumors, history of ovarian therapy; 4.Polycystic ovarian syndrome; 5.Congenital uterine anomalies; 6.Severe endometriosis; 7.Autoimmune disease, history of severe familial genetic disease, etc; 8.HIV positive, hepatitis virus positive and abnormal liver function; 9.Patients with allergic constitution, hyaluronic acid, human blood albumin allergy; 10.Acute or chronic infection, hematologic disease, angiocardiopathy, pulmonary disease, liver disease, nephropathy, pancreas disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Follicle-stimulating hormone; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy rate;Anti-Mullerian Hormone (AMH) ;Number of sinus follicles;Estradiol (E2);Ovarian volume;Luteinizing hormone; | — |
Countries
China
Contacts
Public ContactXu Shaohua
Shanghai First Maternity and Infant Hospital
Outcome results
None listed