Methylmalonic aciduria
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
1 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1.The diagnosis of MMA was consistent with cblC type of deficiency of both heart and spleen; 2.With complications of cognitive impairment, (WISC-IV) scale score IQ below 90; 3.The age ranged from 1 to 6 years old; 4.The legal guardian of the child signed the informed consent and was willing to accept traditional Chinese medicine treatment and clinical investigation.
Exclusion criteria
Exclusion criteria: 1.Patients with severe visual impairment, hearing impairment and cardiovascular and cerebrovascular diseases were present; 2.Patients with other diseases that seriously affect cognitive function, such as hypothyroidism and hydrocephalus; 3.Patients with severe infection, abnormal liver and kidney function and metabolic disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wechsler Intelligence Scale Fourth Edition (WISC-IV); | — |
Secondary
| Measure | Time frame |
|---|---|
| Infant-Social life ability scale for infant junior high school students (S-M); | — |
Countries
China
Contacts
Public ContactLu Xiangpeng
The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
Outcome results
None listed