treatment-resistant psychiatry disorders
Conditions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients aged 12-45 years; 2. Patients who meet the diagnostic criteria of DSM-IV for treatment-resistant depression and schizophrenia; 3. Fully understand the purpose, method, process, possible discomfort, and risk of the experiment, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Concomitant major medical disorders; 2. Neurological disorders or history of head trauma with loss of consciousness >= 5 min; 3. Suicidal ideation or suicidal attempt; 4. IQ < 70; 5. Pregnancy; 6. Substance/alcohol abuse or dependence; 7. MRI contraindications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale, HAMD;MRI;Brief Psychiatric Rating Scale, BPRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale, HAMA ;Young Mania Rating Scale, YMRS;Patien Health Questionnare, PHQ-9;Generalized Anxiexy Disorde-7, GAD-7;MATRICS Consensus Cognitive Battery, MCCB;Wsiconsin card sorting test, WCST); | — |
Countries
China
Contacts
The First Affiliated Hospital of China Medical University