sleep disorder in patients with end-stage renal disease and maintenance hemodialysis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Patients with end-stage renal disease (ESRD) maintenance hemodialysis with sleep disturbances: 1.All patients met the internationally recognized guidelines for chronic kidney disease developed by the American Kidney Foundation and were diagnosed by the following criteria: glomerular filtration rate <15mL/min/1.73m22) 2.ESRD patients received regular HD treatment and their condition was relatively stable; 3.No history of kidney transplantation or acute renal failure; 4.Meet the diagnostic criteria for sleep disorders; 5.<= 18 years old <= 80 years old, willing to participate in this study, and signed the informed consent, can cooperate; 6.No contraindication of MRI examination. End-stage renal disease maintenance hemodialysis patients without sleep disorders: all but 4).
Exclusion criteria
Exclusion criteria: Patients with end-stage renal disease and maintenance hemodialysis: 1. Patients with mental disorders, long-term use of antipsychotic drugs or dependence on drug sleep-aid therapy; 2. Complicated with serious complications, such as severe heart failure, acute pulmonary edema, severe infection, tumor and other diseases; 3. Dementia, Parkinson's disease or other neurodegenerative diseases; 4. Cranial magnetic resonance examination indicated intracranial cerebrovascular disease, tumor and other organic lesions; 5. Those who cannot complete the clinical scale test; 6. Patients with contraindication to MRI examination; 7. History of trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PSQI; | — |
Secondary
| Measure | Time frame |
|---|---|
| MMSE;SDS;SAS;COMPASS-31;HRV;Functional magnetic resonance imaging index (ALFF/fALFF/ReHo/FC/DTI/ASL/ICA/complex networks/SVM/brain structure index, etc.);ISI;ESS;SF-36;PROMIS;FS14; | — |
Countries
China
Contacts
Department of Radiology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine