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Collection and analysis of gingival crevicular fluid

Novel periodontitis point-of-care testing system for the detection of gingival crevicular fluid biomarkers

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100045267
Enrollment
Unknown
Registered
2021-04-10
Start date
2021-05-01
Completion date
Unknown
Last updated
2021-11-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis

Interventions

compare&#32
levels&#32
of&#32
inflammatory&#32
factors&#32
(IL-1ß,MMP-8&#32
TNF-a)&#32
miRNA&#32
(miR-146&#32
miR-155)&#32
from&#32
gingival&#32
crevicular&#32
fluid&#32
and&#32
Gold Standard:Clinical indicators, including PD, BOP, BI, CAL, BL, missing teeth, PLI, etc..
Index test:Detect&#32

Sponsors

College of Stomatology, Xi'an Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.There is no gender limit, and the age limit is between 18-65 years old; 2.Except for the third molar, there are more than 20 remaining teeth in the whole mouth.

Exclusion criteria

Exclusion criteria: 1.History of periodontal treatment within 12 months; 2.Systemic diseases; 3.Subjects had used antibiotics, immunosuppressants or anti-inflammatory drugs within 3 months; 4.Smoking; 5.Pregnancy or breastfeeding.

Design outcomes

Primary

MeasureTime frame
concentration of Interleukin-1ß;concentration of MMP-8;Tumor necrosis factor-a concentration;expression level of miR-146a;expression level of miR-155;—

Countries

China

Contacts

Public ContactLi Ang

College of Stomatology, Xi'an Jiaotong University

drliang@xjtu.edu.cn+86 18792434536

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026