Knee osteoarthritis
Conditions
Interventions
trial group:intraarticular injections of autologous stem cell
Sponsors
The Third Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age:45 ~75; 2.Diagnosis of knee osteoarthritis according to clinical and radiographic criteria defined by the American Society of Rheumatology (standing anterophotograph); 3.Positive floating patellar test; 4.Ultrasound or NMR showed synovial thickening >=1mm, or synovial thickness >=2mm; 5.Imaging showed joint space stenosis (JSN) score >=1; 6.VAS score >=4; 7.IL-6 concentration >=7pg/ml in the articular fluid detected by ELISA.
Exclusion criteria
Exclusion criteria: 1.A history of knee surgery or arthroscopic surgery; 2.Body mass index (BMI) >= 35kg/m2; 3.Knee injection history within the previous month; 4.A history of knee infection; 5.Take opioids daily; 6.The illness is serious enough to prevent participation in activities, such as attendance at scheduled examinations, etc ..
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone and Joint Index (WOMAC) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| the score on the Global Rating of Change scale;timed "up and go" test;Alternate Step Test; | — |
Countries
China
Contacts
Public ContactWang Fei
The Third Hospital of Hebei Medical University
Outcome results
None listed