acute ischemic stroke
Conditions
Interventions
experimental group:Immediately after recanalization, give nitroglycerin into the catheter, volume 10ml (800ug), time 10min
control group:Immediately after recanalization, 10ml of normal saline was given into the catheter for 10 minutes
Sponsors
Beijing Luhe Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Acute ischemic stroke; 2.CTA, MRA or DSA shows occlusion of large vessels; 3.Between 18 and 80 years old; 4.Less than 6 hours from the onset of stroke to groin puncture; 5.The degree of neurological deficits NIHSS score > 6 points, ASPECT > 5 points.
Exclusion criteria
Exclusion criteria: 1.The state of the nervous system improves spontaneously and rapidly to NIHSS 2; 6.The systolic blood pressure before GTN administration is less than 120mmHg; 7.Blood sugar 22.2 mmol/L; 8.Blood coagulation disorders, platelets 50 seconds, INR > 3.0 (9) Pregnancy or contraindications to nitroglycerin; 9.Are participating in other clinical trials; 10.No informed consent was signed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptomatic intracranial hemorrhage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Rankin scale;National Institutes of Health Stroke Scale;Infarct volume;episodes of hypotension needing clinical intervention;neurological deterioration;Fatal cerebral hemorrhage;death during the study period regardless of cause;headache, tachycardia, emesis, and seizures; | — |
Countries
China
Contacts
Public ContactGeng Xiaokun
Beijing Luhe Hospital, Capital Medical University
Outcome results
None listed