Male infertility
Conditions
Interventions
Tadalafil group :Tadalafil
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
Male
Age
20 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1.Aged 20-55 years, male; 2.The body is generally healthy and has a stable heterosexual partner for more than 3 months; 3.The patient has a normal sexual life and has not taken contraceptive measures for 6 months and above without contraception and infertility; 4.Check if the partner's reproductive function is abnormal; 5.The total number of forward motile sperm >= 5 x 10^6; 6.The patient did not use drugs to improve sperm quality within one month before entering the clinical study, or used it, but the one-month washout period has ended; 7.Using the International Index of Erectile Function (IIEF-5) to diagnose ED, patients with mild to moderate ED (IIEF-5 between 11 and 25); 8.Those who have not used PDE5i or other ED treatment methods within 2 weeks before grouping; 9.The patient voluntarily participated and signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Those who take anti-epileptic, anti-tumor and other drugs that affect spermatogenesis; 2.Patients with congenital testicular dysplasia, testicular atrophy, seminal tract obstruction, and varicocele; 3.Exclude patients with serious systemic diseases such as mental illness, cardiovascular and cerebrovascular diseases, liver and kidney insufficiency; 4.Endocrine ED caused by severe endocrine disorders or abnormal sex hormones or ED caused by neurological factors; 5.Vascular ED caused by penile artery and cavernous lesions; 6.Anyone with severe mental illness, spinal cord injury, abnormal penile anatomy, or suffering from penile hemangioma; 7.Use anti-androgens and androgen drugs; coagulation dysfunction and use anticoagulants (such as Coumadin) and other drug-induced ED; 8.Those who are known to be allergic to the research drug and its excipients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total mobile sperm count; | — |
Countries
China
Contacts
Public ContactLi Zheng
Shanghai General Hospital
Outcome results
None listed