Parkinson's disease
Conditions
Interventions
The ketogenic diet group: ketogenic diet
Sponsors
The Fourth Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. According to the clinical diagnostic criteria of PD published by the Movement Disorders Association in 2015, clinically confirmed patients with primary Parkinson's disease; 2. No digestive system diseases, such as inflammatory enteritis, liver, gallbladder and pancreatic diseases;No digestive system stones and surgery; 3. Not taking any antibiotics in the last 3 months; 4. No diabetes and autoimmune diseases; 5. No familial aggregation of Parkinson's disease.
Exclusion criteria
Exclusion criteria: 1. All subjects were excluded from familial Parkinson's disease, Parkinson's superimposed syndrome, and secondary Parkinson's syndrome induced by cerebrovascular disease and poisoning. 2. In addition, subjects in both groups should exclude the following conditions: (1) Drugs and drugs: any drugs and drugs abuse, any regular use in the past 2 months (> 2 times) the following drugs: opioids, lopebutamine, inhaled beta-blockers or anticholinergics, glucocorticoids (oral or extraenteral), tricyclic antidepressants, antihistamines and anticholinergics (except for signs of PD), metoclopramide, cholinergics, doperidone, and proton pump inhibitors; (2) Organ failure: heart failure (excluding: cardiac function grade <= 2), known severe renal insufficiency (glomerular filtration rate < 30ml/min); (3) Other: B vitamin deficiency, serious uterine prolapse, peritonitis, the history of severe endometriosis, polyneuropathy, polio, symptomatic peripheral atherosclerosis (e.g., claudication), aortic aneurysm or dissection, lungs, or skin cancer, stomach, intestines, or urogenital fistula, any of the following happened 2 month before : one of severe hypokalemia or hyperkalemia requiring hospitalization, coma or gastrointestinal endoscopy, abdominal trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parkinson's disease related scale;Changes in intestinal flora;Changes in inflammatory cytokines; | — |
Countries
China
Contacts
Public ContactChi Chunling
The Fourth Affiliated Hospital of Harbin Medical University
Outcome results
None listed