Peritoneal metastasis of carcinoma
Conditions
Interventions
Treatment group 2:When the chemotherapy medicines cause leukopenia or thrombocytopenia, Hematopoietic Stimulating Factors (HSF) can be given as a supportive treatment
Treatment group 3:When the subject is vomiting due to the chemotherapy, anti-emetic agents can be given.
Sponsors
Zhongshan Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Pathologically or cytologically confirmed pectoral or ventral or pelvic malignancy, positive peritoneal metastasis of these cancer or positive exfoliated cells of these cancer were detected in peritoneal lavage fluid; 2.Moderate or greater amount of pleural and peritoneal effusion.Definition of moderate ascites, ultrasonic examination of ascites in decubitus position (>= 3cm) ultrasound examination of pleural effusion in sitting position (>= 4cm) accompanied with clinical symptoms (Chest tightness, shortness of breath, abdominal distension and discomfort); 3.Age 18-75 years old; 4.Male or non-pregnant or lactating women; 5.Bone marrow reserve function is good, blood routine meets the following conditions: white blood cell (>3.5 *10^9/L), neutrophil (>1.5 *10^9/L), platelet(>100 *10^9/L), hemoglobin (>90 g/L); 6.Good organ function, biochemical examination met the following conditions: ALT < 2.5 * ULN, AST < 2.5 * ULN, serum total bilirubin < 1.5 * ULN, serum creatinine < 1.5 * ULN; 7.ECOG <= 1; 8.Voluntary signing of informed consent.
Exclusion criteria
Exclusion criteria: 1.Drug allergy history of TNF and its derivatives; 2.Pregnant or lactating women, women of child-bearing age who were not willing to use contraception during the study periodOr men are unwilling to use effective contraceptives during treatment and for the next year; 3.Patients with severe or uncontrolled medical diseases and infections (including atrial fibrillation, angina pectoris, cardiac insufficiency, ejection fraction less than 50%, uncontrollable hypertension, body temperature > 38 degrees C, etc.); 4.Encapsulated pleural effusion; 5.Severe hypoproteinemia; 6.HIV positive and active hepatitis; 7.Patients who need to be treated for epileptic seizures (e.g. steroids or antiepileptic therapy; 8.Patients with severe or uncontrollable mental illness; 9.Drug abuse and medical, psychological or social conditions may interfere with patients'participation in research or influence the evaluation of research results; 10.Any unstable conditions or situations that may endanger the safety and compliance of patients; 11.Receiving anticancer drugs from other clinical trials; 12.Researchers believe that patients should not participate in other situations of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Drainage volume;Extubation time of drainage tube;Length of stays;Postoperative complications (adhesions, abdominal pain, fever, chills, etc.); | — |
Countries
China
Contacts
Public ContactZhang Huatang, Meng Jincheng
Zhongshan Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine
Outcome results
None listed