cerebral small vessel disease
Conditions
Interventions
cerebral small vessel disease cognitive impairment:NIl
control group:NIl
Sponsors
The Sixth Medical Center of PLA General Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 45-80 years. 2.Comply with CSVD (cerebral small vessel disease, CSVD) related cognitive dysfunction Chinese diagnosis and treatment guidelines for CICSVD diagnostic criteria: A: Cognitive dysfunction: cognitive impairment with subjective reports and cognitive impairment in objective examinations. (1) Mild cognitive impairment: 1) There is a cognitive decline in one or more cognitive functional domains; 2) Cognitive dysfunction is not enough to affect life independence. (2) Dementia or severe cognitive impairment: 1) Obstacles of >= 2 cognitive domains; 2) Cognitive deficits are sufficient to cause impaired independence in life. B Make sure there is CSVD Tips for the first routine imaging (mainly MRI) before or after coming to the hospital (1) There are multiple lacunar infarcts in the sub-cortex, white matter, and deep gray matter, and there may be new ones; (2) Ischemic white matter changes; (3) The space around the blood vessel is enlarged; (4) Microinfarction and CMB. C. There is one of the following evidence to determine the relevant evidence that CSVD causes cognitive impairment. Clinical evidence: (1) or (2). (1) Cognitive impairment and CSVD events are related in time and location. Evidence of cerebrovascular events: stroke history records, stroke signs; (2) No cerebrovascular disease event occurred but the information processing speed, complex attention, executive function were significantly impaired, and at least one of the following symptoms existed at the same time: early gait disorder, early urination control disorder (unexplained by urinary system disease) , Personality and emotional disorder. Imaging evidence is sufficient to explain the existence of cognitive dysfunction, (1) or (2). (1) There are more than 2 lacunar infarcts other than the brainstem, and 1 to 2 lacunar infarcts in key parts simultaneously have extensive white matter hyperintensity; (2) Extensive WML: extensive periventricular and deep white matter damage, extensive cap (measured in parallel to the ventricle>10 mm), or irregular halo (measured in the vertical ventricle>10mm wide, with irregular edges in the periventricular white matter lesions) And extend to the deep part) and diffuse fusion of white matter hyperintensity ( > 25mm, irregular shape) or extensive white matter changes (diffuse white matter hyperintensity without focal injury) and deep gray matter luminal infarction. 3.Sign the informed consent form. 4.People with severe cognitive impairment must have an escort and/or caregiver who is familiar with their living conditions. 5.No fear of claustrophobia, no contraindications for MRI examination, no obvious head tremor, and further MRI examinations can be completed.
Exclusion criteria
Exclusion criteria: 1.Are sufficient to explain other imaging change of cognitive impairment or disease: cortex and/or subcortical lacunar infarction, cerebral hemorrhage, alzheimer's disease and DLB, frontotemporal dementia (FTD), Parkinson's disease, brain tumors (past or current diagnosis of benign meningioma, but researchers think no clinical significance and is unlikely to lead to cognitive impairment of patients will not be ruled out), hydrocephalus, trauma, syphilis, acquired immune deficiency syndrome, such as creutzfeldt-jakob disease; 2.Patients with secondary white matter lesions: demyelination, metabolic, immune (such as sarcoidosis), poisoning, infection, brain radiation therapy and other causes of white matter lesions; 3.Severe diabetes (HbA1c > 9%); 4.Severe heart failure and coronary stenosis; 5.Pregnancy, lactation or possible pregnancy and planning pregnancy; 6.Moderate and severe anxiety, depression, bipolar disorder, severe mental illness (schizophrenia), epilepsy, alcohol and drug abuse, poisoning and metabolic abnormalities; 7.The researcher thinks that it is not suitable for participants; 8.Patients who could not follow up as required during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Deep cerebral medullary vein curvature; | — |
Countries
China
Contacts
Public ContactQian Hairong
The Sixth Medical Center of PLA General Hospital
Outcome results
None listed