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Effect of intravenous ibuprofen on emergence agitation in children undergoing tonsillectomy with propofol anaesthesia: a double-blind, placebo-controlled, randomized study

Effect of intravenous ibuprofen on emergence agitation in children undergoing tonsillectomy with propofol anaesthesia: a double-blind, placebo-controlled, randomized study

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100045128
Enrollment
Unknown
Registered
2021-04-07
Start date
2021-04-12
Completion date
Unknown
Last updated
2021-11-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

emergence agitation

Interventions

experimental roup:Intravenous ibuprofen
control group:placebo

Sponsors

Beijing Children's Hospital, Capital Medical University, National Center for Children's Health
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Years to 9 Years

Inclusion criteria

Inclusion criteria: 1. Aged 3-9 years. 2. With an American Society of Anesthesiologists (ASA) risk score of I–II. 3. Receive selective tonsillectomy (with or without adenoidectomy). 4. Before the start of any activities related to the trial, the subjects legal guardian signs an informed consent, has a full understanding of the purpose and significance of the trial, and is willing to abide by the trial protocol.

Exclusion criteria

Exclusion criteria: 1. With allergy to the study drugs. 2. With bleeding tendency. 3. With abnormal electrolyte balance. 4. With neurological, neuromuscular. 5. With renal or hepatic disease. 6. With craniofacial abnormalities. 7. With cardiac or respiratory disease. 8. With hypertension. 9. With Aspirin sensitive asthma. 10. In a coma.

Design outcomes

Primary

MeasureTime frame
emergence agitation;

Secondary

MeasureTime frame
pain;emergence time;remedy;postoperative nausea and vomiting;

Countries

China

Contacts

Public ContactGao Zhengzheng

Beijing Children's Hospital, Capital Medical University, National Center for Children's Health

110822625@qq.com+86 10 59616415

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 12, 2026