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Observation on the effectiveness and safety of sodium bicarbonate Ringer's solution in the early resuscitation of traumatic hemorrhagic shock: a clinical single-center prospective randomized controlled trial

Observation on the effectiveness and safety of sodium bicarbonate Ringer's solution in the early resuscitation of traumatic hemorrhagic shock: a clinical single-center prospective randomized controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100045044
Enrollment
Unknown
Registered
2021-04-04
Start date
2021-05-01
Completion date
Unknown
Last updated
2021-11-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic hemorrhagic shock

Interventions

Sodium bicarbonate Ringer solution group:Only use Sodium bicarbonate Ringer solution in the early fluid resuscitation
Sodium lactate Ringer solution group:Only use Sodium lactate Ringer solution in the early fluid resuscitation

Sponsors

The Third Affiliated Hospital of Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1.Patients with traumatic hemorrhagic shock; 2.Aged >= 18 years.

Exclusion criteria

Exclusion criteria: 1.Severe brainstem failure, severe cardiopulmonary dysfunction and severe hepatorenal insufficiency; 2.Patients with traumatic brain injury(TBI); 3.Patients with hypermagnesemia and hypothyroidism; 4.Pregnant or breast-feeding patients; 5.Used acid correction drugs; 6.Any condition that, in the investigators opinion, makes the individual unsuitable for study participation (to be documented); 7.Inability to provide informed consent; 8.Patients who automatically gave up treatment or died during the study.

Design outcomes

Primary

MeasureTime frame
Duration of shock;Lactic acid clearance rate of 6H;

Secondary

MeasureTime frame
Blood gas index;Temperature;Blood coagulation function;Recurrence rate of shock;Inflammatory mediator level;Resuscitation fluid and drugs usage;7-day mortality;Duration of mechanical ventilation;Duration of ICU stay;Duration of hospital;Incidence of Complication;

Countries

China

Contacts

Public ContactLiu Chengyong

The Third Affiliated Hospital of Southern Medical University

648817770@qq.com+86 13503048718

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 13, 2026