Periodontitis Stage III
Conditions
Interventions
Probiotics group:Periodontal basic treatment + probiotic lozenges
Placebo group:Periodontal basic treatment + placebo lozenges
Sponsors
Peking University School and Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
35 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Aged 35-60 years; 2.Patients with stage III localized or extensive periodontitis (New classification criteria for periodontal disease in 2018): CAL heaviest point on adjacent surface >= 5mm, radiographic bone loss was 1/3 or more of the root, with = 6mm, vertical bone absorption was >= 3mm, the root forking lesion was II or III degree, and the alveolar ridge defect was moderate. When the percentage of affected teeth conforming to the heaviest stage was = 30% was extensive type. 3.At least 2 affected teeth in each quadrant PPD >= 5mm, CAL >= 4mm; 4.Remaining teeth >= 20 (excluding teeth to be extracted), a minimum of 5 natural teeth in each quadrant, excluding third molars; 5.Overall health.
Exclusion criteria
Exclusion criteria: 1.Pregnancy and nursing women; 2.Having received periodontal treatment in the past 6 months; 3.Having received antibiotics for any purpose within 3 months prior to entering the study; prophylactic use of antibiotics needed before periodontal therapy; 4.Use of medication which may affect periodontal tissue, such as non-steroidal anti-inflammatory drugs; 5.Smoke; 6.Wearing a fixed orthodontic appliances; 7.Caries and bad restorations at the sampling sites; 8.Cardiovascular disease, lung disease, liver disease, immune system disease or diabetes; 9.Lactose or yogurt allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Probing pocket depth; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gingival recession;Clinical attachment loss;Bleeding on probing;Bleeding index;Plaque index; | — |
Countries
China
Contacts
Public ContactOuyang Xiangying
Peking University School and Hospital of Stomatology
Outcome results
None listed