Patients requiring sedation in the ICU
Conditions
Interventions
Remazolam besylate group:Sedation with remazolam besylate
Midazolam group:sedation with midazolam
Sponsors
Affiliated Hospital of Putian University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 and 3 days; 3. Obtain informed consent from patients or family members.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or breastfeeding; 2. Those who need general anesthesia surgery within 48 hours; 3. Severe, existing substantial liver disease with clinically significant portal hypertension, Child-Pugh C cirrhosis or acute liver failure; 4. Patients with acute or chronic renal insufficiency requiring dialysis; 5. Severe head injury, brain tumor, increased intracranial pressure, cerebrovascular accident, coma, status epilepticus, etc.; 6. Patients with a history of alcohol or drug abuse; 7. Any situation that hinders the correct assessment of cognitive function, such as language and sensory disorders or mental disorders (language difficulties or mental organic dysfunction); 8. Participate in other exploratory clinical trials within 6 months before screening; 9. Known or suspected allergy to remazolam, midazolam and opioids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The average total dose required for propofol remediation to maintain target sedation;the time of mechanical ventilation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs;APACHE II score;Blood routine examination; | — |
Countries
China
Contacts
Public ContactChen Ming
Affiliated Hospital of Putian University
Outcome results
None listed