esophageal squamous cell carcinoma
Conditions
Interventions
Treatment group:Radiotherapy combined with Pembrolizumab
Sponsors
Mianyang Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18-80 years; 2.Esophageal squamous cell carcinoma (ESCC) diagnosed by pathology and imaging at the first diagnosis; 3.Metastatic oligometastasis occurred after receiving radical treatment in the past, and the interval between first diagnosis and oligometastasis is greater than or equal to 6 months; 4.The imaging evaluation is less than or equal to 5 oligometastatic lesions, less than or equal to two oligometastatic organs, and a single organ has less than or equal to 3 metastatic lesions; 5.Unable to perform surgical treatment on metastatic lesions due to iatrogenic or (and) personal factors; 6.Satisfactory control of primary disease; 7.All metastatic tumors can be treated with IMRT; 8.ECOG physical status score: 0-1 points, Karnofsky score >= 60, able to tolerate radiotherapy; 9.The estimated survival period is >= 3 months; 10.Sign the informed consent form; 11.The compliance is good, and the family members agree to cooperate with the survival follow-up.
Exclusion criteria
Exclusion criteria: 1.Pregnant or breastfeeding women; 2.Allogeneic organ transplantation or allogeneic bone marrow transplantation; 3.Immune system diseases such as Crohn's disease, ulcerative colitis, lupus erythematosus, etc.; 4.A known history of human immunodeficiency virus (HIV) positive test or known acquired immunodeficiency syndrome (AIDS); 5.Severe heart, lung, kidney, and liver diseases; 6.The active period of viral hepatitis; 7.According to the judgment of the investigator, there are accompanying diseases that seriously endanger the safety of the patient or affect the completion of the study; 8.Severe hypertension, diabetes mellitus.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression free survival; | — |
Countries
China
Contacts
Public ContactLi Jie
Mianyang Central Hospital
Outcome results
None listed