Nonalcoholic fatty liver disease
Conditions
Interventions
control group:Glutathione
experimental group:Glutathione+polyethylene glycol losartan
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged > 18 years; 2. In accordance with NASH diagnostic criteria (guidelines for prevention and treatment of nonalcoholic fatty liver disease, 2018).
Exclusion criteria
Exclusion criteria: 1. Patients with uncontrolled type 2 diabetes defined as HbA1c >= 9.5% during the screening period; (retested during the screening period for subjects with HbA1c>= 9.5%)and basal insulin dose adjustment >10% within 60 days before enrollment, and need to use glucagon-like peptide analogs or complex oral anti-diabetic (OAD) regimens (3 or more OADs) within 6 months before screening, and have a history of severe hypoglycemia in the past year (symptomatic hypoglycemia that requires external assistance to restore normal nervous system state); 3. Alcoholic, drug, viral, autoimmune, hereditary hepatitis; 4. Pregnant and lactating women; 5. With previous history of pancreatitis; 6. With pancreatitis warning / thyroid cancer; 7. Patients with hematopoietic system diseases; 8. Patients with liver cancer; 9. Incomplete data collection; 10. Without informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood fat;Fasting blood glucose;HbA1c;Serum insulin;HOMA-IR;Cytokeratin CK-18 (M30 and M65);Transabdominal ultrasound;Fat content determination;Liver elasticity value; | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight;Waistline;BMI;Heart function;Liver function;Kidney function;Routine blood test; | — |
Countries
China
Contacts
Public ContactZhang Yu
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed