Elderly patients with cognitive impairment
Conditions
Interventions
Sponsors
Fujian Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=60 years; 2. Meet the diagnostic criteria of SCD, MCI, and mild and moderate AD; 3. Those who can communicate normally in Mandarin and can cooperate to complete the scale assessment; 4. Volunteer to participate in this research.
Exclusion criteria
Exclusion criteria: 1. Persons with a history of mental illness or congenital mental retardation; 2. Patients with severe cardiopulmonary, liver and kidney dysfunction, severe endocrine diseases, severe infectious diseases, severe anemia and toxic encephalopathy; 3. Cerebrovascular disease, Parkinson's disease, brain trauma, encephalitis, epilepsy, brain tumor, long-term diarrhea or malnutrition (vitamin deficiency), thyroid dysfunction, blood transfusion or metallurgy history, alcoholism, CO poisoning, drug abuse, syphilis and AIDS, etc.; 4. Contraindications for MRI examination, such as accompanied by metal implants such as pacemaker, arterial stent, aneurysm clip, dental implant, claustrophobia and so on; 5. The patients who participated in MRI scanning were assessed as right-handed on the handedness scale.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal cognitive assessment, MoCA;Mini-mental state examination, MMSE; | — |
Secondary
| Measure | Time frame |
|---|---|
| Auditory verbal learning test, AVLT;Verbal fluency tests, VFT;Boston naming test, BNT;Shape trails test, STT;Rey – Osterrieth complex figure test, ROCFT;Activity of daily living, ADL;Functional activities questionnaire,FAQ;Geriatric Depression Scale, GDS;Self-rating Anxiety Scale, SAS;Quality of life-Alzheimer's disease, QOL-AD;P300;MRI Scans;Blood biological indicators; | — |
Countries
China
Contacts
Public ContactLi Hong
Fujian Medical University
Outcome results
None listed