disorders of consciousness
Conditions
Interventions
Treatment group:Transcranial magnetic stimulation therapy, conventional medication therapy, rehabilitation therapy
Control group:Conventional medication therapy, rehabilitation therapy
Sponsors
Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients over 18 years old; 2.Patients whose disease interval is more than 1 month and less than 1 year; 3.Based on the Coma Recovery Scale-revised (CRS-R) and GCS scale scores, patients diagnosed as mimimally conscious state, vegetative state and coma, and no serious brain stem lesions were found; 4.Patients with stable vital signs; 5.All hemorrhage lesions in patients with cerebral hemorrhage are completely absorbed; 6.Conduct CRS-R evaluation every other day within a week, and the score is stable in the same interval; 7.Patient's family members agree the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patient who has a history of epilepsy;patient's first-degree relatives have a history of idiopathic epilepsy and the use of epileptic drugs; EEG shows epileptiform discharge; 2.Patients with hypoxic-ischemic encephalopathy; 3.There is a shunt in the patient's brain; 4.There is an implantable cardiac pacemaker, cardiac catheter or electronic pump in the patient's heart; 5.There is a metal aneurysm clip in the patient's brain; 6.There are metal nails or vascular suture devices in the patient's brain; 7.There are neurostimulators or brain/subdural electrodes in the patient's brain; 8.Patients who use metal plates to close the skull defect at the TMS stimulation site; 9.Patients with extensive skin damage; 10.Patients with complications such as acute myocardial infarction, pulmonary embolism, acute infection, sepsis, severe anemia, etc.; 11.Patients with other serious systemic diseases or clinical critical conditions (respiratory or hemodynamic instability).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The score of the Coma Recovery Scale-Revised; | — |
Secondary
| Measure | Time frame |
|---|---|
| The score of the Glasgow coma sacle;The score of the Chinese vegetative state scale;The score of the Clinical global impression-improvement;Quantitative EEG power analysis;Motor evoked potential;Brainstem auditory evoked potential;Somatosensory evoked potential;Occurrence of adverse events; | — |
Countries
China
Contacts
Public ContactLu Xiao
Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed