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The influence and mechanism of alcohol on human cortical function and cognition

The influence and mechanism of alcohol on human cortical function and cognition

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100044916
Enrollment
Unknown
Registered
2021-03-31
Start date
2021-03-31
Completion date
Unknown
Last updated
2021-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcohol Use Disorders (AUDs)

Interventions

Alcohol Group-1.5g/L:Drinking alcoholic beverages (1.5g/L)
Alcohol group-1.0g/L:Drinking beverage with alcohol(1.0g/L)
Control gruop:Drinking beverage

Sponsors

Yixing Jiurucheng Rehabilitation Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.As assessed using the "Alcohol Timeline Follow-Back", participants are required to experience at least one heavy drinking episode within the last month. Heavy drinking episode was defined at 5 standard drinks for male and 4 standard drinks for female according to NIAAA2014 guidelines; 2.Particiants are of legal drinking age in China (from 18 to 60 years); 3.Participants are non-smokers (had no smoked any cigarettes in the last 3 months); 4.Any substance abuse, dependence, or mental illness that does not meet the DSM-IV definition.

Exclusion criteria

Exclusion criteria: 1.Participants had a history of seizures, neurological disease or cognitive impairment (a total score <24 on the Mini Mental State Examination); 2.Participants have used of any therapeutic or recreational psychoactive drugs within the last 3 months; 3.Female participants were pregnant or breast feeding.

Design outcomes

Primary

MeasureTime frame
Resting Moter Threshold (RMT);MEP latency;Long Interval Intracortical Inhibition (LICI);Short Interval Intracortical Inhibition (SICI);Short Interval Cortical Facilitation (SICF);Intracortical Inhibition (ICF);Cortical Silent Period (SP);Inhibition control;Working Memory;Risky decision making;Risk and ambiguity decision making;

Countries

China

Contacts

Public ContactLiu Hao

Yixing Jiurucheng Rehabilitation Hospital

liuhao0909@163.com+86 13961506516

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026