postoperative cognitive
Conditions
Interventions
TaVNS group (Pain related subgroup):Transcutaneous auricular vagus nerve stimulation
Control group (Pain related subgroup):Sham stimulation
TaVNS group (Cognitive function related subgroup):Transcutaneous auricular vagus nerve stimulation
Control group (Cognitive function related subgroup):Sham stimulation
Sponsors
The Third Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Hebei medical university third hospital for orthopaedic surgery patients with general anesthesia; 2. ASA class I-III; 3. 18= 65 years old).
Exclusion criteria
Exclusion criteria: 1. Have a history of long-term use of analgesic drugs for chronic pain; 2. History of use of psychiatric drugs (including opioids, NSAIDs, sedatives, and antidepressants); 3. Patients with local sensory loss and hypersensitivity to electricity; 4. Patients with pacemakers; 5. A pregnant or parturient woman; 6. Do not agree to participate in the study; 7. Patients that researchers believe not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological testing;MMSE;Inflammatory factor;Characteristics of patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score;BIS;Cerebral oxygen saturation;Postoperative complications; | — |
Countries
China
Contacts
Public ContactWang Qiujun
The Third Hospital of Hebei Medical University
Outcome results
None listed