Cervical insufficiency during pregnancy
Conditions
Interventions
=28 weeks:Nil
high risk pregnant women vs. non high risk pregnant women:Nil
Sponsors
Women's Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Study group 1: pregnant women with high risk factors of premature delivery. Inclusion criteria for study group 1: 1.Pregnant women at 11-14 weeks of gestation; 2.Pregnant women with high risk of premature delivery include: (1)Those with late abortion and / or premature delivery history; (2)Vaginal ultrasound examination: the cervical length found by vaginal ultrasound in the second trimester of pregnancy is less than 25 mm; (3)Those with a history of cervical surgery; (4)Those who are too young or too old: pregnant women 35 years old; (5)Those who have too short pregnancy interval (less than 6 months); (6)Those who have too thin body mass index < 19 kg / m^2, or the weight of pregnancies is less than 50kg; (7)Multiple pregnancies; (8)Assisted reproductive technology; (9)Abnormal fetal and amniotic fluid volume; (10)Pregnancy complications or complications; (11)Bad habits such as tobacco and alcohol. 3.Sign informed consent. Study group 2: pregnant women without high risk of premature delivery. Inclusion criteria for study group 2: 1.Normal singleton pregnant women excluding high risk factors, pregnant 11-14 weeks; 2.Sign informed consent.
Exclusion criteria
Exclusion criteria: Patients meeting any of the following criteria will be excluded from the study: 1.Suffering from diseases unfavorable to the trial or threatening other participants, such as mental diseases; 2.Unable to cooperate with test operation; 3.The quality of ultrasonic image is poor, which can not meet the requirements of parameter measurement and analysis; 4.Congenital malformation of fetus; 5.Pregnant women who cannot obtain pregnancy outcome; 6.Iatrogenic premature delivery or induced labor; 7.The basic information is incomplete.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| elasticity contrast index;internal ostium(IOS)/external ostium(EOS);hardness rati;internal ostium(IOS)/external ostium(EOS);cervix length;gestational age; | — |
Secondary
| Measure | Time frame |
|---|---|
| weight;height;body mass index (BMI);newborn weight;Apgar score;delivery gestational age;fertilization way;delivery way;pregnant women age;uterine dysplasia; | — |
Countries
China
Contacts
Public ContactLu Hong
Women's Hospital, Zhejiang University School of Medicine
Outcome results
None listed