Stress response and immune function
Conditions
Interventions
Observation group:Patients in the observation group were given intravenous injection of 0.5mg/kg esketamine before induction of anesthesia, and diluted with 0.25mg/kg/h esketamine to 50ml intravenous
Control group:The PCIA regimen of the control group was Kaifen 100mg+ondansetron 16mg+esketamine 100mg.
Sponsors
Women and Children's Hospital, School of Medicine, Xiamen university
Eligibility
Sex/Gender
Female
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosed stage I and stage II breast cancer by imaging features and histopathological examination; 2.American Association of Anesthesiologists (ASA) grade I-II; 3.There are no obvious abnormalities in organs such as heart, liver, kidney, etc. Lesions; 4.The expected survival time is> 6 months, and the Karnofsky score is > 60 points.
Exclusion criteria
Exclusion criteria: 1.Recent use of hormonal drugs; 2.Confusion, mental illness; 3.Preoperative chemotherapy and radiotherapy; 4.Recurrence of breast cancer, combined with other malignant tumors; 5.Severe electrolyte imbalance; 6.Long-term use of sedative or analgesic drugs; 7.Pregnancy or lactation stage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Angiotensin-II (ANG-II);Aldosterone (ALD);Cortisol;Tumor Necrosis Factor (TNF)-a;Total T cells in peripheral blood;B lymphocytes;NK cells;The amount of sufentanil, the amount of remifentanil, the residence time in the recovery room, the time of extubation from anesthesia, and the time of awakening from anesthesia were recorded for the two groups of patients during surgery.;Adverse reactions in the wake of the two groups of patients after the operation: chills, restlessness, tachycardia, increased secretions, respiratory depression, hypertension, hallucinations; | — |
Countries
China
Contacts
Public ContactJia Junxiang
Women and Children's Hospital, School of Medicine, Xiamen university
Outcome results
None listed