Block between mother and infant
Conditions
Interventions
breast feeding group: Tenofovir treatment
artificial feeding group: Tenofovir treatment
Sponsors
Beijing Youan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1.Deliverable infants of chronic hepatitis B pregnant women with HBsAg positive >=6 months; 2.Mothers need to continue oral tenofovir treatment after delivery; 3.Before delivery, the mother had five items of hepatitis B, HBV-DNA quantification, genotype, HBV-DNA sequence, liver function, blood routine, B-ultrasound of liver and gallbladder, and the relevant information was complete; 4.In the obstetrics department of our hospital, they can continue to follow up the mother and child according to the program requirements, and sign the informed consent, and their compliance is good.
Exclusion criteria
Exclusion criteria: 1.Complicated with HCV, HIV, HDV, HEV Treponema pallidum infection; 2.Diagnosed or suspected hepatocellular carcinoma or other malignant tumors; 3.Long-term use of hormones or immunosuppressants; 4.Allergic history to nucleoside analogues; 5.Prenatal diagnosis of fetal congenital malformations; 6.Severe diseases of pregnant women with other organs affect follow-up compliance of patients. 7.Creatinine clearance rate (CLCr) < 100 mL/min (Cockcroft-Gault method); 8.Low phosphorus and hypocalcemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bone mineral density; | — |
Secondary
| Measure | Time frame |
|---|---|
| physical development;adverse events; | — |
Countries
China
Contacts
Public ContactZhu Yunxia
Beijing Youan Hospital, Capital Medical University
Outcome results
None listed