Severe Novel Coronavirus Pneumonia (COVID-19), COPD, ARDS
Conditions
Interventions
No atomization group:Bacterial filters are placed in the respiratory circuit
Compound ipratropium bromide solution atomization group:Bacterial filters were placed in the respiratory circuit and atomized with Compound ipratropium bromide solution
Amphotericin B atomization group:Bacterial filters were placed in the respiratory circuit and atomized with amphotericin B
Interferon atomization group:Bacterial filters were placed in the respiratory circuit and atomized with interferon
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Dec.1, 2020 solstice Admitted to intensive care unit of the First Affiliated Hospital of Guangzhou Medical University on Jan. 1, 2021. 2. The duration of mechanical ventilation was > 72 hours. 3. Use bacterial filters in the breathing loop. 4. During mechanical ventilation, they were atomized with amphotericin B, cobivent or interferon. 5.Subjects voluntarily participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Inability to tolerate or other reasons to interrupt atomization treatment in the atomization process. 2. Patient died.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Pressure before filtering;Post-filtration pressure;Gas flow rate; | — |
Primary
| Measure | Time frame |
|---|---|
| Bacterial filter resistance; | — |
Countries
China
Contacts
Public ContactXu Yuanda
Guangzhou Medical University
Outcome results
None listed