The efficacy and pharmacokinetic characteristics of colistin sulfate in the treatment of ICU patients with severe infection: a prospective, multicenter observational study

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100044866

Enrollment

Unknown

Registered

2021-03-30

Start date

2021-04-20

Completion date

Unknown

Last updated

2021-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

observation group:colistin sulfate

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Aged >=18 years; 2. Patients with severe infection treated with colistin sulfate; 3. Patients or their family members voluntarily participated in this study and signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients who received other polymyxins within 7 days before inclusion; 2. People known to be allergic to colistin sulfate; 3. Expected survival time < 4 days; 4. Pregnancy test is positive or breastfeeding.

Design outcomes

Primary

Measure	Time frame
Clinical improvement rate;Pharmacokinetic characteristics;	—

Secondary

Measure	Time frame
SOFA score;Incidence of adverse reactions;	—

Countries

China

Contacts

Public ContactShao Huanzhang

Henan Provincial People's Hospital

shaohuanzhang@sina.com+86 18538297681

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026