Acute large vessel occlusion stroke
Conditions
Interventions
Case series:Mechanical thrombectomy
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 110 Years
Inclusion criteria
Inclusion criteria: 1. Aged more than 18 years; 2. Clinical diagnosis of ischaemic stroke; the symptoms of stroke last for more than 30 min and has not significantly relieved before treatment; 3. Modified Rankin Score less than 2 before this stroke; 4. Onset to puncture time less than 12 hours for anterior circulation stroke and less than 24 hours for posterior circulation stroke; 5. CTA, MRA or DSA was performed when clinical symptoms severity suggested proximal vessel occlusion, including internal carotid artery, middle cerebral artery (MCA)M1/M2 segment, basilar artery occlusions or dominant vertebral artery occlusions.
Exclusion criteria
Exclusion criteria: 1. Acute Stroke Prognosis Early CT score (ASPECTS) 0-6 by baseline non-contrast CT or diffusion-weighted image (DWI) in the territory of symptomatic intracranial occlusion or DWI lesion volume >70 mL for anterior circulation, or posterior circulation (pc-ASPECTS) 0-6, or Pons-midbrain index for posterior circulation; 2. Seizure at the beginning of stroke; 3. Prior stroke within the last 3 months; 4. Pre-existing neurological or psychiatric disease; 5. With less than 3 months life expectancy; 6. Previous clinical history of disease of intracranial hemorrhage, subarachnoid hemorrhage (SAH), arteriovenous malformation AVM) or tumor; 7. Increased bleeding risk disease during the last 90 days; 8. In the past 10 days with the history of hemorrhagic disease, significant trauma, or major surgery; 9. Uncompensated hypertension (systolic blood pressure more than 185 mm Hg or diastolic blood pressure more than 110 mm Hg), renal failure; 10. Platelet count less than 50x103, blood glucose less than 2.8 or more than 22.2 mmol/L; 11. Coagulation factor deficiency or under oral anticoagulant therapy with International Normalization Ratio (INR) >3.0; 12. Contraindications of digital subtraction angiography (DSA) examination; 13. Pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional Outcome;Degree of vascular recanalization;Intracranial Hemorrhages;Symptomatic Intracranial Hemorrhages;Routine blood indexes;Biochemical indexes;CRP;IL-6;IL-1 beta;Myoglobin, MRP8/14, NGAL, MMP-2, OPN, MPO, SAA, IGFBP-4, ICAM-1, VCAM-1, MMP-9, Cystatin C, IFN-alpha, IFN-gama, TNF-alpha, MCP-1, IL-8, IL-10, IL-12 p70, IL-17A, IL-18, IL-23, IL-33.;Other serum markers; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recurrent stroke (including ICH, sICH, ischemic stroke);Other vascular events (including Myocardial infarction, pulmonary embolism, Deep venous thrombosis, etc.;The volume of the ischemic lesion;Aspect Score;NIHSS;Clot Burden;Death of any cause; | — |
Countries
China
Contacts
Public ContactDapeng Mo
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed