Treatment-refractory depression
Conditions
Interventions
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients group: (1) Be able to communicate and provide written consent; (2) Diagnosis of major depression identified by treating psychiatrists and confirmed via a checklist of Diagnostic and Statistical Manual of Mental Disorders-4th edition (DSM-IV) criteria and meets the criteria for TRD (TRD is defined as an insufficient therapeutic response to >=2 adequate antidepressants treatment trials during the current episode), no gender limitations; (3) Aged 18–65 years; (4) A total score >= 17 on the 17-item Hamilton Rating Scale for Depression (HAMD-17) at screening; (5) With junior middle school and above years of schooling; (6) With Han nationality and right handedness. 2.Healthy control group: (1) The subjects or their relatives of the third generation of two lineages did not meet any diagnostic criteria of mental illness in DSM-IV, and were not related to the patients group; (2) Enrollment criteria for the same patients group (4)-(6).
Exclusion criteria
Exclusion criteria: 1. Patients group: (1) With other major psychiatric disorders that meet the DSM-IV diagnostic criteria include organic mental disorders, alcohol dependence, drug dependence/abuse, schizophrenia, etc; (2) Currently, there are serious and unstable somatic diseases such as diabetes, thyroid disease, hypertension, heart disease and narrow-angle glaucoma, etc; Wechsler intelligence test (WAIS-RC) full scale IQ (FIQ) total scores <= 80; (3) With a history of neurological diseases such as epilepsy and dementia; (4) Subjects with metal in the body, such as pacemaker or brain electrode; (5) With previous history of anesthetics allergy; (6) Subjects who are at the stage of pre-pregnancy, pregnancy or lataction; (7) With contraindications to MRI or intolerant of MRI scanning environment, such as claustrophobia. 2. Healty control group: the same as the patient group(The age, gender and years of education were matched with the patients group).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| efficacy;safety;tolerability; | — |
Countries
China
Contacts
Public ContactZheng Wei
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital)
Outcome results
None listed