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Research on methylation of BDNF gene as a biomarker of Tai-chi to alleviate depression in the elderly and its associated mechanism

Research on methylation of BDNF gene as a biomarker of Tai-chi to alleviate depression in the elderly and its associated mechanism

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100044836
Enrollment
Unknown
Registered
2021-03-30
Start date
2021-04-01
Completion date
Unknown
Last updated
2021-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Geriatric depression

Interventions

experimental group:24-movement Yang's Tai Chi

Sponsors

West China Second University Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
60 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Aged 60 years or above; 2. Dwelled in the targeted community for at least one year; 3. With physical condition that allows regular Tai Chi exercise; 4. With normal hearing; 5. Be able to understand words (cooperate with the questionnaire filling); 6. PHQ-9 score greater than or equal to 5 points.

Exclusion criteria

Exclusion criteria: 1. With diseases which are not safe to perform Tai Chi exercise (such as severe hypertension, stroke history in the last 6 months, etc.); 2. Practiced Tai Chi exercise regularrly in the past 1 year; 3. Patients with major depressive disorder (PHQ-9 score 20 or greater).

Design outcomes

Primary

MeasureTime frame
brain derived neurotrophic factor, BDNF;nicotinamide adenine dinucleotide, NAD;SIRT1;—

Countries

China

Contacts

Public ContactLiao Shujuan

West China Second University Hospital, Sichuan University

254651946@qq.com+86 13882442594

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026