Rapid Intravenous Glyceryl Trinitrate in Ischemic Damage (RIGID) after Stroke: a Rationale, Design and Protocol for Prospective Randomized Controlled Trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100044801

Enrollment

Unknown

Registered

2021-03-27

Start date

2021-04-01

Completion date

Unknown

Last updated

2021-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

GTN group:GTN 5 mg/d, with a speed of GTN 0.4 mg/h, for 2 days

Control group:Intravenous administration of equal capacity of 0.9% normal saline total 50 ml/day, 4 ml/h , for 2 days

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged >= 18 and =3 and 90 (95 or 100), mRS <=2; 6. Informed consent provided by participant or legally authorized representative.

Exclusion criteria

Exclusion criteria: 1. Hemodynamic instability, including persistent low systolic blood pressure (SBP) and SBP<=100 mmHg despite standard treatment; 2. Severe anemia, HGB <=60g/L; 3. Glaucoma; 4. Allergy to GTN; 5. Participant in another ongoing clinical trial; 6. Life expectancy of fewer than 1 year due to comorbidities.

Design outcomes

Primary

Measure	Time frame
90d mRS;	—

Secondary

Measure	Time frame
90d mRS 0-2 rate;90-day mortality rate ;	—

Countries

China

Contacts

Public ContactGeng Xiaokun

Beijing Luhe Hospital, Capital Medical University

xgeng@ccmu.edu.cn+86 1831055270

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026