Alzheimer's disease
Conditions
Interventions
Electropuncture plus donepezil group:Electropuncture (3 times/w) + donepezil (5mg, Qd)
Sham Electropuncture plus donepezil group:Sham Electropuncture (3 times/w) + donepezil (5mg, Qd)
Sponsors
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. This study is designed to include participants aged 50-80 years with diagnosis of mild AD according to NIA-AA criteria or with a CDR score between 0.5 and 1. 2. The subject included are required to have no history of taking anti-dementia drugs systematically (donepezil excluded); 3. At least one reliable caretaker who can accompany the subject during treatment is also needed.
Exclusion criteria
Exclusion criteria: 1. Individuals will be excluded if they have dementia caused by other diseases other than AD, such as cer-ebrovascular diseases, Creutzfeldt-Jakob disease and Parkinsons disease; 2. A history of psychological disorders (DSM-IV criteria); 3. Uncorrectable visual or auditory impairment that hampers the completion of related examination; 4. Patients could not participate this study if they are allergic to acupuncture or pace-maker installed; 5. Pre-menopausal women will also be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer’s disease Assessment Scale-Cognitive Subscale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Activities of Daily Living Scales;functional Magnetic Resonance Imaging, fMRI;magnetoencephalography, MEG; | — |
Countries
China
Contacts
Public ContactWang Gang
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed