Diabetic Kidney Disease
Conditions
Interventions
Sponsors
Shandong Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.In patients with type 2 diabetic nephropathy, persistent albuminuria, 2 consecutive urine tests within 3 months of urine microalbumin/creatinine (UACR) >= 30mg/g; 2.Glomerular filtration rate eGFR>=45ml/min/1.73m2, and required to remain stable during the trial (eGFR decreased <=25% from the beginning of screening to the second week of follow-up); 3.Patients with deficiency of qi and yin and blood stasis; 4.No gender limit, age 18-80 years old, BMI <= 45 kg/m2; 5.Glycated hemoglobin (HbA1c) 6-11% , fasting blood glucose (FPG) <= 15 mmol/l; 6.Systolic/Diastolic blood pressure (SBP/DBP) <=180/100 mmHg (sitting position); 7.Volunteer to participate and cooperate with physicians, sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Recent acute complications of diabetes such as hypoglycemia coma, diabetic ketosis, lactic acidosis, etc. 2.Patients with heart failure and myocardial infarction; combined infection, immune disease, malignant tumor; combined with liver disease (ALT, AST or ALP levels exceed three times the upper limit of normal); 3.Male serum creatinine (SCr)>= 1.50 mg or Fmale serum creatinine (SCr) >= 1.40 mg; 4.People with a history of nephrotic syndrome or inflammatory kidney disease in the past 3 months, or other causes such as excessive exercise, heart failure, infectious febrile diseases, and urinary tract infections that lead to elevated urine microprotein; 5.Those who have used nephrotoxic drugs and antioxidants within the past 2 weeks, or have been treated with glucocorticoids systemically; 6.Patients requiring dialysis or kidney transplantation; 7.History of bariatric surgery or other gastrointestinal surgery causing chronic malabsorption within 2 years; 8.Patients with drug contraindications: pregnant or breastfeeding women, allergic physiques, and those who are allergic to the drug used in this test; 9.Epidemiological history; 10.Others who cannot cooperate, such as mental patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urinary albumin-creatinin ration;glomerular filtration rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum creatinine;blood urea nitrogen;fasting blood-glucose;glycated hemoglobin;blood lipid profile;liver ultrasound;fundus examination;routine urine test; | — |
Countries
China
Contacts
Public ContactZhao Jiajun
Shandong Provincial Hospital
Outcome results
None listed