Gastrointestinal dysfunction and its effect on perioperative neurocognitive dysfunction in patients after spinal surgery under general anesthesia

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100044770

Enrollment

Unknown

Registered

2021-03-27

Start date

2021-04-06

Completion date

Unknown

Last updated

2021-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative Neurocognitive Dysfunction

Interventions

Drug group: Mosapride citrate tablets (5mg), three times a day for 3 days

Postoperative pseudophagous group:Chew sugar-free gum, 3 times a day, for half an hour each time until exhaustion

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients undergoing general anesthesia; 2.Aged >= 50 years; 3.Patients who underwent thoracic/lumbar fusion at selected time; 4.Not illiterate and willing to cooperate to complete the test; 5.Conduct ethical review and sign informed consent.

Exclusion criteria

Exclusion criteria: 1.Preoperative complications of gastrointestinal and other digestive system diseases; 2.Taking gastrointestinal motility drugs/antibiotics; 3.With mental or nervous system diseases.

Design outcomes

Primary

Measure	Time frame
Lipopolysaccharide;Matrix metalloprotease-9;Neurofilament light;diamine oxidase;intestinal fatty acid binding protein;	—

Countries

China

Contacts

Public ContactZheng Xu

Department of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School

28123-happy@163.com+86 18761679064

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026