A pilot study on the role of topical Cenegermin in enhancing regeneration of corneal nerves after small incision lenticule extraction (SMILE)

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100044759

Enrollment

Unknown

Registered

2021-03-26

Start date

2021-03-26

Completion date

Unknown

Last updated

2021-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post refractive surgury

Interventions

Right eye :Senecimin drops

Left eye:placebo (normal saline)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged 18 years and above; 2. Patients after routine bilateral small incision lenticule extraction(SMILE); 3. difference of the spherical equivalent of each eye is within -1.00D preoperatively.

Exclusion criteria

Exclusion criteria: With history of wearing contact lenses preoperatively.

Design outcomes

Primary

Measure	Time frame
Tear break-up time;	—

Secondary

Measure	Time frame
Corneal fluorescence staining;Schirmer I test;	—

Countries

China

Contacts

Public ContactZhou Xingtao

The Eye and ENT Hospital of Fudan University

doctzhouxingtao@163.com+86 13816880725

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026