Research on Altered Dynamic Functional Network Connectivity in Stroke Patients with Hand Dysfunction

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100044753

Enrollment

Unknown

Registered

2021-03-26

Start date

2021-04-01

Completion date

Unknown

Last updated

2021-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Stroke patients group:Nil

Healthy control group:Nil

Eligibility

Sex/Gender

All

Age

30 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Stroke Patient Group: (1) Subjects comply with the diagnostic criteria of "Stroke" in the 2010 "Guidelines for the Prevention and Treatment of Cerebrovascular Diseases in China" and confirmed by head CT or MRI; (2) With first onset unilateral subcortical stroke; (3) Age ranged from 30 to 75 years; (4) Right-handedness before stroke; (5) Greater than three months since stroke onset and Brunnstrom graded as III-VI; (6) The condition and vital signs are stable; (7) Voluntarily participated and signed the informed consent form. 2. Healthy Control Group: (1) Age ranged from 30 to 75 years; (2) Right-handedness; (3) Be able to carry out daily activities independently; (4) No severe dysfunction of movement, vision, hearing, and language; (5) No previous history of head trauma, cerebrovascular disease, neurological disease, mental illness; (6) No history of smoking, alcohol dependency, and application of addictive drugs; (7) Subjects or their immediate family signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Subjects with any contraindications for MRI examination; 2. Subjects with history of other brain diseases and drug dependency; 3. Subjects with unstable conditions or accompanied by malignant and rapidly progressing diseases, such as severe atrial fibrillation; 4. Subjects with serious communication barriers, cognitive impairment, or cooperation with difficulties.

Design outcomes

Primary

Measure	Time frame
Multimodal MRI;Fugl-Meyer Assessment of Upper Extremity Upper;	—

Secondary

Measure	Time frame
Broetz Hand Test;Placebo Test;Modified Barthel Index;Hamilton Depression Scale;Putonghua Version of the Oxford Cognitive Screen;	—

Countries

China

Contacts

Public ContactXu Rong, Zhao Zhiyong

Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School

xurong3973@163.com+86 15951935159, +86 18818208393

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026