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Biomarker identification for early diagnosis of Kawasaki disease based on single-cell sequencing

Biomarker identification for early diagnosis of Kawasaki disease based on single-cell sequencing

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100044729
Enrollment
Unknown
Registered
2021-03-26
Start date
2019-12-24
Completion date
Unknown
Last updated
2021-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kawasaki disease

Interventions

case group :IVIG treatment
fever control group:antibiotic therapy

Sponsors

Children's Hospital of Shanghai
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 5 Years

Inclusion criteria

Inclusion criteria: We intend to select 10 kawasaki disease children as the case group.10 children as fever control group. 1.Inclusion criteria: All children met the diagnostic criteria established by the American Heart Association (AHA) in 2017 : a.Fever lasts for 5 days or more, excluding other diseases with similar manifestations; b.Extremities: Acute phase: erythema of palm (foot), finger (toe) end swelling;Convalescent period: 2 ~ 3 weeks occurrence finger (toe) nail edge desquamination; c.Pleomorphic rash; d.Both sides of the ball combined membrane hyperemia without secretions; e. Changes in the lips and mouth: redness of the lips and mouth, chapped lips, diffuse congestion of the bayberry tongue, mouth and pharynx mucosa; f.Cervical lymph node lesions (diameter > 1.5 cm), usually unilateral; 2. Inclusion criteria of fever control group: (1) All conform to China's 2013 revised guidelines for the management of community-acquired pneumonia in children; (2) Fever days more than 4 days; (3) Children with a history of KD were excluded. All the subjects in the case group and the fever control group were Han nationality children and were not related to each other.

Exclusion criteria

Exclusion criteria: Exclusion criteria for fever control group: children with a history of KD were excluded.

Design outcomes

Primary

MeasureTime frame
cytokins;

Countries

China

Contacts

Public ContactMin Huang

Children's Hospital of Shanghai

huangmin@sjtu.edu.cn+86 18917128118

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026