pancreatic cancer
Conditions
Interventions
experimental group:Ultrasound microbubble therapy for chemotherapy
control group:chemotherapy
Sponsors
Department of Ultrasound, Cancer Center of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The patients with locally advanced pancreatic cancer (stage III) with or without distant metastasis (stage IV); confirmed by histopathology or cytology were unresectable, regardless of the number of metastases; 2. Age 18-75 years old, male or female; 3. Oncological evaluation (ultrasound, CT or MRI) showed measurable and evaluable tumor lesions; 4. The estimated survival time was more than 3 months; 5. WBC >= 3.5x 10^9/L, ANC >= 1.5 x 10^9/L, PLT >= 80 x 10^9/L, Hb>= 90/L; 6. There was no significant abnormality in liver and kidney function: ALT and AST <= 2.5 times of the upper limit of normal value, urea and Cr <= 1,25 times of the upper limit of normal value, ALT and AST <= 5 times of the upper limit of normal value in patients with liver metastasis; 7. Cardiopulmonary function was basically normal; 8. There was no history of other malignant tumors; 9. Good compliance, no mental disorder.
Exclusion criteria
Exclusion criteria: 1. Pregnancy or lactation; 2. Allergic to chemotherapeutic drugs and hypersensitivity constitution; 3. Intestinal obstruction or incomplete intestinal obstruction; 4. There was a large amount of ascites; 5. With brain and bone metastasis; 6. Receiving other anti-tumor drugs or radiotherapy; 7. At the same time to participate in other clinical trials or chemotherapy end time is less than 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cycle number of ultrasound treatment;Disease control rate; | — |
Countries
China
Contacts
Public ContactZheng Liu
Department of ultrasound, Xinqiao Hospital, Chongqing
Outcome results
None listed