gout
Conditions
Interventions
A:low dose IL-2 treatment
B:injection of normal saline
Sponsors
The First Affiliated Hospital of USTC
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Voluntarily participate in and sign the informed consent; 2. Aged 18-65 years, male; 3. The patient's diagnosis of gout was clear and in line with the 2015 ACR / EULAR criteria for gout diagnosis; 4. In half a year, the number of gout attacks >= 6 or the latest one lasts for 1 month without relief.
Exclusion criteria
Exclusion criteria: 1. Those with infection and other inflammatory diseases; 2. Patients with other chronic consumptive diseases; 3. Taking other drugs unrelated to gout at the same time; 4. ALT and AST were more than 2 times of the upper limit of normal value; 5. Renal function damage, Cr >= 1.5 mg / dl (133 µ mol / L) or bun >= 1.5 times the upper limit of normal value.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency, degree and duration of gout;Changes in the number of regulatory T cells in peripheral blood; | — |
Secondary
| Measure | Time frame |
|---|---|
| ESR, C-reactive protein, etc;Serum levels of IL-1 ß, TGF - ß and expression of IL-1 ß, TGF - ß mRNA in PBMC;Blood uric acid level;Blood uric acid level;Types and accumulation of anti-inflammatory and analgesic drugs used by patients; | — |
Countries
China
Contacts
Public ContactJinhui Tao
The First Affiliated Hospital of USTC
Outcome results
None listed