the effectiveness of trigeminal nerve stimulation on brain activity in patients with chronic disturbance of consciousness

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100044693

Enrollment

Unknown

Registered

2021-03-25

Start date

2021-03-26

Completion date

Unknown

Last updated

2021-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic disturbance of consciousness

Interventions

experimental group:Percutaneous electrical trigeminal nerve stimulation

control group:sham stimulation

Eligibility

Sex/Gender

All

Age

25 Years to 65 Years

Inclusion criteria

Inclusion criteria: VS diagnostic criteria: 1) Unconscious of the surrounding environment. 2) No visual tracking and response to speech. 3) Functional preservation of hypothalamus and brainstem. 4) To respond to external stimuli, there may be independent frowning, crying, etc. 5) There are sleep and awakening cycles. 6) Primitive reflex exists, and other reflexes such as grip, light reflex and tendon reflex may exist. 7) There is random movement. 8) Blood pressure control and cardiopulmonary function are intact, and there may be fecal incontinence. MCS diagnostic criteria: 1) Follow simple instructions. 2) Gestures or oral answers to questions (but inaccurate). 3) Emergency action or emotional response to the environment. 4) Follow or gaze with eyeballs.

Exclusion criteria

Exclusion criteria: Extensive skin damage and infection in the head and face; diabetes; other diseases with unstable vital signs; use of sedatives or anesthetics.

Design outcomes

Primary

Measure	Time frame
brain metabolism;	—

Countries

China

Contacts

Public ContactChao Ma

107 Yanjiang west road, Guangzhou, Guangdong province

Ma-chaoqq@126.com+86 13688869781

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026