Research on the Efficacy and Its Antidepressant Mechanism of Transcranial Magnetic Stimulation under Neuronavigation in the Treatment of Late Life Depression

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100044691

Enrollment

Unknown

Registered

2021-03-25

Start date

2021-04-01

Completion date

Unknown

Last updated

2021-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Late life depression

Interventions

Active group:iTBS + Antidepressant

sham group:sham + Antidepressant

Eligibility

Sex/Gender

All

Age

55 Years to 85 Years

Inclusion criteria

Inclusion criteria: Aged >= 60 years, right-handed; in line with DSM-IV "major depressive disorder" diagnostic criteria, current HAMD-17 score >= 17; the medication regimen remains unchanged two weeks before treatment and during the study period; agree to participate in this study and sign Make informed consent.

Exclusion criteria

Exclusion criteria: Meet any other diagnostic criteria of DSM-IV axis I; hypothyroidism, vitamin B12 or folic acid deficiency, syphilis infection, stroke; heart, liver, kidney and other physical diseases cannot tolerate this study; there are contraindications for TMS treatment, MRI examination, etc. disease.

Design outcomes

Primary

Measure	Time frame
Hamilton Depression Rating Scale;	—

Secondary

Measure	Time frame
Hamilton Anxiety Rating Scale;	—

Countries

China

Contacts

Public ContactYuping Ning

The Affiliated Brain Hospital of Guangzhou Medical University

ningjeny@126.com+86 23 81268720

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026