severe periodontitis
Conditions
Interventions
Experimental group:Non flap regeneration assisted by endoscope
Sponsors
Nanjing Stomatological Hospital Medical School of Nanjing University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. The age is 18-65 years old, and the gender is unlimited. 2. According to the diagnostic criteria of international classification of periodontal diseases in 1999, the patients were clinically diagnosed as aggressive periodontitis; according to the staging criteria of periodontitis in the new international classification of periodontal diseases and peri implant diseases in 2018, the patients were classified as stage III C. 3. Only isolated lesions need surgical treatment, and all the following conditions are met: 1) PD >= 7 mm at baseline; 2) After debridement, there was a vertical bone defect on the adjacent surface of the tooth surface, and the depth of the vertical bone defect was more than or equal to 4 mm, with at least one bone wall; 3) Keratinized gingiva with a width of more than or equal to 2 mm can completely cover the bone defect and implant; 4) X-ray showed that the base of the bone bag was at least 3 mm in the crown of the root tip. 4. The teeth were treated with scaling and curettage within one month. 5. The amount of plaque control was less than 20% at baseline. 6. The furcation lesions of the test teeth were less than or equal to grade II, and the loosening degree was less than or equal to grade I.
Exclusion criteria
Exclusion criteria: 1. The experimental teeth had a history of open debridement within one year; 2. Known to be allergic to animal derived collagen; 3. Clinical or radiological findings showed that there were acute infection, apical lesions, root fracture, severe root deformity, cementum beads, hard to remove cementum enamel protrusion, untreated caries at the enamel cementum boundary (CEJ) or root surface, and the restoration reached subgingival and / or the edge of restoration at or below CEJ was not close; 4. All kinds of subjects can cause artifacts in oral imaging examination, such as: the study teeth and their adjacent teeth are metal dentures and porcelain fused to metal teeth; 5. Patients with history of diabetes or abnormal blood glucose detection (fasting blood glucose >= 7 mmol / L); 6. Abnormal liver and kidney function (AST, ALT >= 1.5 fold ULN, creatinine >= 1.5 fold ULN); 7. Patients with severe endocrine and metabolic diseases; 8. The patients with three-level hypertension had osteoporosis and autoimmune diseases; 9. Who is not suitable for surgery due to the history of malignant tumor or other serious diseases 10. Patients who were using steroids that interfere with calcium metabolism within 3 months prior to informed consent bookmarking.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gingival Recession;Angle and height of bone absorption in X-ray films;Attachment Loss;Plaque Index;Probing Depth;Bleeding On Probing; | — |
Countries
China
Contacts
Public ContactLI HOUXUAN
Nanjing Stomatological Hospital Medical School of Nanjing University
Outcome results
None listed