behavioral and psychological symptoms of dementia
Conditions
Interventions
Combined stimulation group:Subjects received rTMS true stimulation combined with tDCS true stimulation
Single rTMS stimulation group:Subjects receive rTMS true stimulus and tDCS false stimulus
Single tDCS stimulation group:Subjects receive rTMS false stimulus and tDCS true stimulus
Control group:The electromagnetic stimuli received by the subjects are all pseudo stimuli
Sponsors
Beijing Geriatric Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Right-handed; 2. Gender is not limited, age 60-90 years; 3. AD diagnosis meets NINCDS-ADRDA diagnosis is likely to be AD, and at the same time meets the clinical dementia severity score (CDR) >= 2 points and the disease course is within 10 years; 4. There are mental symptoms (such as hallucinations, delusions, etc.), behavioral symptoms (such as nighttime behavioral stereotypes, aggression, disinhibition, etc.), emotional symptoms (such as depression/unhappy mood, anxiety, euphoria, over-excitement/high mood, etc.) And other mental and behavioral symptoms; 5. Educational level is junior high school and above; 6. Can cooperate to complete neuropsychological assessment and head MRI and TMS-EEG examinations, without examination contraindications; 7. If you are taking AD drugs, you need to take the drugs. >= 4 weeks, and no drug dosage adjustment during the treatment period; 8. Subjects or immediate family members agree to participate in this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those with functional failure and critical illness of important organs (heart, lung, liver, kidney, etc.); 2. Those with metal implants such as cardiac pacemakers, coronary stents and aneurysm clips, and artificial implants. Into the cochlea and other ferromagnetic materials. 3. People with severe visual and hearing impairment; 4. People who are undergoing other clinical trials; 5. People who have history of infectious diseases, brain trauma and surgery; 6. People who have alcoholism and drug addiction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychiatric Inventory, NPI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Geriatric Depression Scale;Pittsburgh Sleep Quality Index, PSQI;Mini-mental State Examination, MMSE;Montreal Cognitive Assessment, MoCA;Alzheimer' s Disease Assessment Scale-cognitive subscale, ADAS-Cog;Barthel Index, BI;fMRI, TMS-EEG?resting state EEG; | — |
Countries
China
Contacts
Public ContactYueqing Hu
Beijing Geriatric Hospital
Outcome results
None listed