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Comparison of the effects of DEB-TACE and c-TACE on cellular immune function in patients with hepatocellular carcinoma: a single-center prospective study

Comparison of the effects of DEB-TACE and c-TACE on cellular immune function in patients with hepatocellular carcinoma: a single-center prospective study

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100044594
Enrollment
Unknown
Registered
2021-03-24
Start date
2021-04-01
Completion date
Unknown
Last updated
2021-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary liver cancer

Interventions

experimental group:Chemoembolization with Drug-Eluting Beads

Sponsors

Fujian Medical University Union Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) The diagnosis is in accordance with the standard of diagnosis and treatment for primary liver cancer (2019 edition) and the initial treatment of patients with CNLC staging (Stage I A-III B) , in which stage I A-II B must be inoperable or inoperable or unwilling to undergo the above treatment and require TACE treatment and signature; (2) Liver function Child-Pugh grade A or B; (3) Eastern Cooperative Oncology Group Performance Status (ECOG PS)0-2; (4) Tumor occupied less than 70% of liver volume; (5) Sign an informed consent form.

Exclusion criteria

Exclusion criteria: (1) Primary malignant tumor with other sites; (2) other operations, ablation or other anti-tumor drugs were performed in the same period; (3) coexisting immune diseases; (4) severe and irreversibly impaired coagulation; (5) the main trunk of portal vein was completely embolized by carcinoma, and less collateral vessels were formed; (6) patients with active hepatitis or severe infection who can not be treated simultaneously; (7) extensive distant metastasis with an estimated survival period of less than 3 months; (8) cachexia or multiple organ failure.

Design outcomes

Primary

MeasureTime frame
T cell subsets;

Secondary

MeasureTime frame
Objective Response Rate;Progression Free Survival;Overall Survival;

Countries

China

Contacts

Public ContactXie Hang

Fujian Medical University Union Hospital

xh_01_01@163.com+86 13763872040

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026