Biliary atresia
Conditions
Interventions
Gold Standard:Intraoperative cholangiography
diagnostic 
system 
for 
atresia 
(Biochemicaltests, 
blood 
ammonia, 
AFP, 
hepatobiliary 
ultrasound)
Sponsors
Children's Hospital Affiliated to Zhejiang University Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Clinical features: a. Skin jaundice, b. Fecal whitening (yellowish, white), c. The color of urine becomes darker, d. Enlarged liver, hardened liver. 2) Blood biochemical characteristics: conjugated bilirubin > 2.0 mg/dL (or 34umol/L), or direct bilirubin / total bilirubin >= 20%. 3) the age is less than 4 months, and the duration of jaundice is longer than the first 2 weeks after birth. 4) the patient's legal representative has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1) TPN-related cholestasis. 2) diseases associated with other major structural malformations. 3) there are known or suspected neuroendocrine or metabolic diseases. 4) past history combined with life-threatening diseases of various organ systems. 5) patients who have participated in other clinical trials in the last 3 months. 6) any other circumstances in which the researchers do not consider it appropriate to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biochemicaltests;hepatobiliary B ultrasound;SEN, SPE, ACC, AUC of ROC; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood routine;CRP;blood ammonia;AFP; | — |
Countries
China
Contacts
Public ContactJinfa Tou
The Children's Hospital of Zhejiang University School of Medicine
Outcome results
None listed