Early goal-directed treatment of patients with septic shock guided by arteriovenous partial pressure difference of carbon dioxide

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100044523

Enrollment

Unknown

Registered

2021-03-23

Start date

2021-04-01

Completion date

Unknown

Last updated

2021-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

septic shock

Interventions

experimental group:Milrinone was given to patients with gap = 6 mmHg

control group:Standardized treatment by clinicians

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged >= 18 and <= 80 years; 2. Septic shock.

Exclusion criteria

Exclusion criteria: 1. Pregnant women; 2. Non resuscitable deathbed or predicted death within 24 hours; 3. With cardiogenic pulmonary edema and primary heart failure (cardiac function grade IV); 4. Severe valvular stenosis and obstructive hypertrophic cardiomyopathy.

Design outcomes

Primary

Measure	Time frame
Central venous partial pressure of carbon dioxide;Arterial partial pressure of carbon dioxide;Arteriovenous carbon dioxide differential pressure;	—

Secondary

Measure	Time frame
Apache II Score;SOFA Score;Lactate level;creatinine;Urine output;Length of ICU stay;Total length of stay;	—

Countries

China

Contacts

Public ContactYu Jiang-Quan

Dalian Medical University

15651057659@163.com+86 18051060659

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026