multiple system atrophy
Conditions
Interventions
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
Male
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age between 30 and 70; (2) Based on the second edition of diagnostic criteria proposed by Gilman in 2008, the clinical diagnosis was in line with "probable MSA"; (3) All patients have been ruled out of polyQ disease by genetic testing; (4) The time between inclusion and diagnosis is no more than 3 years; (5) Patient survival was expected to be at least 3 years, as assessed by the investigator; (6) Volunteering to participate in the study and able to sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Pregnant or lactating female patients; (2) Family history of dyskinesia; (3) Previous history of other neurological diseases; (4) There were other neurological lesions that could not be explained by MSA on MRI at baseline; (5) The following signs indicate that the disease has entered an advanced stage: 1) Severe speech disorders (UMSARS-I item 1 score is greater than or equal to 3 points); 2) Severe dysphagia (UMSARS-I scale item 2 score > or equal to 3); 3) Severe walking disorder (UMSARS-1 item 3 score greater than or equal to 3 points); 4) Frequent falls (Item 8 score of UMSARS-I scale is greater than or equal to 3 points); (6) Other situations that may affect the research object's inability to complete the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified multiple system atrophy rating scale, UMSARS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hoehn&Yahr stage;wexner constipation score;SCOPA-AUT scale;Mini-mental State Examination, MMSE;frontal assessment battery, FAB;The MOS 36-item short-form health survey, SF-36; | — |
Countries
China
Contacts
Public ContactHong Jiang
Xiangya Hospital, Central South University
Outcome results
None listed