Hip arthritis, Femoral neck fracture
Conditions
Interventions
Dexmedetomidine group:Dexmedetomidine maintains sedation
Esketamine group:Esketamine maintains sedation
Sponsors
The Second Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: BMI <= 28kg/m2, able to understand and cooperate with the doctor's conversation.
Exclusion criteria
Exclusion criteria: Patients with psychiatric or neurological diseases, allergic to the drugs used, patients with severe hypertension (arterial systolic blood pressure/diastolic blood pressure >= 180/100mmHg), patients with hyperthyroidism, patients with glaucoma, patients with obvious ischemic heart disease (unstable angina/myocardial infarction occurred in the past 6 months), with contraindications to intraspinal anesthesia (central nervous system disease, severe systemic infection, shock, spinal trauma or history of severe low back pain, significant increase in intra-abdominal pressure, abnormal hemostasis).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative hemodynamic parameters (heart rate, mean arterial pressure);Intraoperative respiratory depression (respiratory frequency <8 breaths/min or a decrease of 25% or more from baseline) and hypoxia (SpO2<90%) frequency and duration of occurrence;Intraoperative sedation (EEG bispectral index, Ramsay sedation score);Postoperative wake-up reactions (including the frequency of nausea and vomiting, dreams, nightmares, dizziness, restlessness); | — |
Countries
China
Contacts
Public ContactXiao Zhaoyang
The Second Affiliated Hospital of Dalian Medical University
Outcome results
None listed