Effects of different frequency deep brain stimulation on cognitive function of Parkinson's disease

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100044479

Enrollment

Unknown

Registered

2021-03-22

Start date

2021-03-20

Completion date

Unknown

Last updated

2022-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

HFS-DBS:High gamma frequency stimulation

LFS-DBS:Low theta frequency stimulation

Off:No stimulation

Eligibility

Sex/Gender

All

Age

45 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 45-75 years. 2. Diagnosis is consistent with idiopathic Parkinson's disease. 3. underwent bilateral DBS surgery. 4. able to participate in the trial and complete all neuropsychological tests. 5. MMSE meets the score of education level. 6. UPDRS-III drug effect rate >= 30%.

Exclusion criteria

Exclusion criteria: 1. The patient refuses to participate in the study and is unwilling or unable to sign the informed consent form. 2. There are mental, psychological, and cognitive impairments that cannot cooperate with surgery and follow-up. 3. Can not walk, or accompanied by other diseases affecting walking distance. 4. There are contraindications for neurosurgery, such as cerebral infarction, hydrocephalus, coagulopathy, etc. 5. There are tumors, liver function, severe renal function abnormalities (index more than 3 times normal) and other concomitant diseases that seriously affect health. 6. There are other neurological lesions, such as intracranial space, cerebrovascular disease, mental illness, etc. 7. Patients cannot be scanned for MRI (such as claustrophobia or implants in the body). 8. There were visual acuity, hearing loss, color blindness or color weakness, which could not cooperate with cognitive test. 9. Patients with severe anxiety and depression.

Design outcomes

Primary

Measure	Time frame
global cognitive-related scale;Executive function-related scale;	—

Secondary

Measure	Time frame
Visuospatial function-related scale;attention-related scale;language-related scale;memory-related scale;Quality of life related scales;MRI data;electrophysiology;	—

Countries

China

Contacts

Public ContactZhang Jianguo

Beijing Tiantan Hospital, Capital Medical University

zjguo73@126.com+86 13601294613

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026