Effects of sodium bicarbonate Ringer injection and sodium lactate Ringer injection on acute renal injury after major abdominal surgery: a randomized, controlled, open-label clinical study

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100044465

Enrollment

Unknown

Registered

2021-03-18

Start date

2021-04-01

Completion date

Unknown

Last updated

2021-09-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute kidney injury

Interventions

BRS group:Sodium Bicarbonate Ringer’s Injection

LRS group:Sodium Lactated Ringer’s Injection

Eligibility

Sex/Gender

All

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1) ASA grade I to III; 2) patients aged between 20 and 70 years, signed informed consent form, and are willing to participate in the study; 3) BMI 70g/L; 9) sinus rhythm was detected by electrocardiogram and there were no other malignant arrhythmias.

Exclusion criteria

Exclusion criteria: 1) Emergency surgery. 2) liver and kidney surgery. 3) complicated with chronic respiratory diseases and FEV1/FVC < 70%. 4) the operation time is less than 2 hours. 5) patients with mental illness or cognitive impairment. 6) uncontrolled hypertension with blood pressure higher than 180 × 100mmHg. 7) patients with hypothyroidism. 8) pregnant or lactating patients.

Design outcomes

Primary

Measure	Time frame
Acute kidney injury;	—

Countries

China

Contacts

Public ContactShiyong Li

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

shiyongli@hust.edu.cn+86 18062154189

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026